A thought-provoking exploration of the plant medicine Huachuma and how its cultural and spiritual heritage is intersecting with modern use of the medicine. Examining how modernity is changing indigenous landscapes and thus necessitating a cultural, ecological and spiritual movement of conservation of huachuma culture and practices. The demands for Huachuma have escalated, posing significant threats to the plant’s native populations and the delicate cultural ecosystems that have nurtured it for generations. We weave in deeply personal, compelling stories and reflections from those who continue to practice traditional rituals and healing with Huachuma, offering viewers a nuanced exploration of the intersection between commerce, culture, and spirituality.